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Through studies of mice and rat models, it has been determined that PPG neurons contain projection tracts to various locations on the brain, including primarily the hypothalamus, supraoptic nucleus, and autonomic regions such as the limbic forebrain, portions of the mesolimbic reward system, and other regions involved in learning and memory [47, 50]

Exendin-4 (an endogenous insulin releasing incretin, GLP-1) reduces A accumulation and tau hyperphosphorylation in cellular and animal models of AD (85, 151, 153156)

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